Risk 2 to 4 times More in Babies Born with Help Of Assisted Methods Than In infants conceived Naturally : StudyInfants conceived with techniques commonly used in fertility clinics are two to four times more likely to have certain birth defects than are infants conceived naturally, a new study has found. The findings applied to single births only, not to twins or other multiples. The defects included heart problems, cleft lip, cleft palate and abnormalities in the esophaemia or rectum. But those conditions are rare to begin with, generally occurring no more than once in 700 births, so the overall risk was still low, even after the fertility treatments, Cleft lip, for instance, typically occurs in 1 in 950 births in the United States, and the study found that the risk about doubled, to approximately 1 in 425, among infants conceived with the fertility treatments. The procedures that increased the risk were so-called assisted reproductive techniques, like in vitro fertilization, which require doctors and technicians to work with eggs and sperm outside the body. The study did not include women who only took fertility drugs and did not have procedures performed, "I think it is important for couples to consider the fact that there may be a risk for birth defects," said Jennita Reefthuis, an epidemiologist at the Centers for Disease control and Prevention, and the first author of the study. But Reefhuis (pronounced REEF-house) also said that although her study linked fertility procedures to birth defects, if did not prove the connection or explain it. If the connection is real, it is known whether the procedures increase the risk for birth defects, or whether infertility itself raises the risk.
Fertility doctors, she said, "may not believe my findings." James Grifo, director of the fertility clinic at New York University Medical Center, said, "the good news is that there risk is low." Grigo said more research was needed o test the findings because the study included only 281 women who had fertility procedures. He did that if the association with birth defects was real, the underlying cause was more likely related to the patients infertility than to the treatments. Twins and other multiple births have a higher risk of birth defects than single births and whether infertility treatment adds to that risk is unknown. Alan Fleischman, vice-president and medical director of the March of Dimes, said: "I think it's an important study. It's confirmatory of the direction we have been concerned about, an increase in some structural birth defects in babies born with assisted reproductive techniques compared to those born with assisted reproductive techniques compared to those born with assisted reproductive techniques compared to those born without such. And yet the numbers are still small, the risks are low". Women considering fertility treatment should be informed that there might be a informed that there might be a risk of birth defects, Fleischman said, but they need not be 'overly concerned'.
CHENNAI: when oocyte (egg), --- life is created. For - a 29 year-old mother, life was created when donor oocyte met sperm in a laboratory in G.G.Hospital here. The result was the country’s first frozen egg baby, a bonnie boy, pre-term, yet doing well at 2.5 Kg.In a planned Cesarean procedure conducted by kamala Selvaraj and Priya Selvaraj and Priya Selvaraj on Wednesday morning, the yet-to be-named baby boy carried gustily as doctors pulled him out. He was transferred to the nursery for observation where he continued to do well. When geneticists told Ms. V, who prefers to remain and famous that her chromosomes abnormality was coming on the way of realizing her domain of holding her own baby in her arms, it strangely cleared the path for future action. As Ms. V's chromosomal defect would render any pregnancy unstable, and any baby so formed abnormal, it was clear that she needed a donor egg. It was with this request that she made her way to G.G. Hospital. "In a way it was good that the geneticist had clarified things for her. By the time she came, there was just one option—of using a frozen donor egg along with the husband's sperm,' says Priya, Selvaraj, who treated Ms. V. The egg, cryopreserved, or stored frozen at sub Zero temperatures, would be thawed, and using the Intra Cytoplasmic Sperm injection procedure integrated with the sperm. "There is so much architecture inside the egg---it carries the entire chromosomal spindle. That makes it difficult to freeze, store and thaw, especially achieve fertilization," Dr. Priya said, Studies in peer-reviewed journals indicate that the mean survival rate of a harvested egg is about percent, the fertilisation rate is 52.5 e cent, the mean pregnancy rate is 1.52 percent and chances of a successful delivery about 2 percent. " It is not much, even in the area of s reproduction techniques. But, in such cases, where there is no other hope for the woman, we go ahead," she added. It was decided to use an egg frozen for six months on Ms. V, as her own eggs could not be used. Led by Dr. Priya, the team, which included S. kalaichelvi, conducted the procedure through the slow freezing method. Two women went in for embryo transfer and it was M.s. V, hailing from Tamil Nadu, who turned out to be the one with all the luck. Part of that luck, she seems to have parceled into a gene gift for her new born son, a gift that, undoubtedly,will serve him well.
Mumbai docs want to try alternative therapy to ensure healthy babies. EVEN as the HC denied Nikita Mehta permission to abort her 25-week-old foetus, two Mumbai doctors are hoping to use alternative therapy that will ensure healthy babies. This treatment can be used when allopathic medicines fail to provide the desired results.
Dr. H S Palep of integrative medicine and Dr. Geeta Niyogi of obstetrics, head of their respective departments at K J Somaiya Medical college, are in talks with the Boston University of Medicine to rest the success of an ayurvedic drug on 300 pregnant women aged 18-44 for healthy babies. The drug called Sujat (See box) claims to strengthen the placenta that supports the foetus.
The research will follow a 'double-blind system where a placebo will be given to 150 expectant mothers and Sujat to the rest. The women will then be tracked for the entire term of their pregnancy. "The average birth weight for an Indian is unable to significantly raise this weight, why, not try alternative medicine," said palep who proposed the same to Dr. Robert Saper of Boston University last year. The initial reaction was skeptical. "Alternative medicine is an important part of the course for medical students in USA, while in India it's virtually ignored," said Palap. The investigators are now waiting for approval from the Indian Council of medical Research and Us NIH/NICHD health authorities to start research.
A combination of nine different ayurvedic ingredients designed to strengthen the placenta of an expecting mother and improve general health.
Despite WHO's updated Reference Range, Most Labs In the City Are Using The Old Criteria for Sperm Count Analysis
One only needs a license under the shop and establishment Act to set up a diagnostic laboratory. The need for standarisation and quality management in diagnostic labs was highlighted by the death of union minister P.R. kumaramangalm in 2000, allegedly due to misdiagnosis. This promoted the Union health ministry to ask state governments to introduce regulatory and quality control mechanisms in the healthcare sector The state government responded with the Maharashtra Clinical Establishments Bill 2001 to regulate nursing homes, Bill 2001 to regulate nursing homes, hospitals and pathology laboratories. A draft of this legislation is awaiting approval of the law and judiciary department The Union government also assigned the national accreditation Board For Testing and calibration Laboratories (NABL) with the task of auditing diagnostic labs. But these audits are voluntary. Pathologists and consumer organisations had opposed a 1998 regulatory proposal to control pathology laboratories
Normal sperm count as set by the WHO is 20 million/Ml and above
But the range followed by a large number of labs in the city is 40 million/ml to 120 million.
Most of these private labs use Neubars Chamber or Meckler chambers to assess the semen count.
Ideally, these tests should be done at centres with computer assisted sperm analysis (CASA)
But there are no labs in the city with CASA.
Moreover, there are only two accredited path labs in the city.
If a sample has less than 20 million sperm per ml, it is considered as low sperm count. Less than 10 million is very low and the technical term for this condition is oligospermia (oligo means few).Azoospermics are those with no sperm at all. This can come as a rude shock to these patients as their semen look absolutely normal, but it is only on microscopic examination that the problem is detected.
If the sperm test is abnormal, at least 3-4 tests over a period of 3-6 months are required to confirm whether the abnormality is persistent or not. So don't jump into conclusions based on just one report. The sperm counts also do tend to vary on their own. It takes six weeks for the testes to produce a new sperm which is why you need to wait before repeating the test. It also makes sense to go to different laboratory for the next test to ensure that the diagnosis is correct. What leads to incorrect semen analysis? Incorrect collection technique
Too much time between collecting the sample and testing
A short interval since the previous ejaculation
Illness in the last 3 months (even a flu or a fever can temporarily depress the count)
You can now shop for sperms in city.
Mumbai: When infertility specialists across the globe are worried about the falling number of sperm donors, an international sperm bank has set up a branch in Mulund with- in a year, the bank will start selling samples to infertility doctors across the country. The reason behind Denmark-based Cryos International starting its Indian operations is simple: huge business potential. Its MD Dilip Patil said, "IVF specialists said there was a need for good quality donor sperm."
Dr Pushpa Mitra Bhargava is a member of the Indian council for Medical Research (ICMR), the committee ----- the guidelines for fertility clinics, look at things more scientifically. "When the new Act on infertility clinics come into force, it will be mandatory to have anonymous donors instead of the current practice of directed donation of sperm (the donor or recipient are decided beforehand),"said the scientist. "Then, this sperm bank-the second stand-alone facility in Maharashtra after the one in Aurangabad –and many more will become al, the more popular."
At present, most infertility clinics have their own sperm banks for patients admitted there. None of them sells sperm to outsiders. However, the new Act will make it compulsory to have individual sperm banks, separate from fertility clinics. "If a person owns an infertility clinic, he cannot operate a sperm bank there, "said Dr. Bhargava.
Dr. Anirudda Malpani who runs of clinic in Colaba, said the only difference between the two is that the new facilities "are willing to sell samples to gynacelogists and clinics, while now, infertility specialists operate captive sperm banks that cater only to their patients.
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